GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Il6 | increases expression | ISO | Il6 (Mus musculus) | 6480464 | CTD | resiquimod results in increased expression of IL6 protein | PMID:33632240 | Il6 | increases expression | ISO | IL6 (Homo sapiens) | 6480464 | CTD | resiquimod results in increased expression of IL6 mRNA; resiquimod results in increased expression of IL6 protein | PMID:28924041 | Il6 | increases secretion | ISO | Il6 (Mus musculus) | 6480464 | CTD | resiquimod results in increased secretion of IL6 protein | PMID:22916010 | Il6 | multiple interactions | ISO | Il6 (Mus musculus) | 6480464 | CTD | LGMN gene mutant form inhibits the reaction [resiquimod results in increased secretion of IL6 protein]; Niclosamide inhibits the reaction [resiquimod results in increased expression of IL6 protein]; resiquimod promotes the reaction [deoxynivalenol results in increased expression of IL6 mRNA] | PMID:16687389 PMID:22916010 PMID:33632240 | Il6 | multiple interactions | ISO | IL6 (Homo sapiens) | 6480464 | CTD | 2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide inhibits the reaction [resiquimod results in increased expression of IL6 protein]; 7-oxozeanol inhibits the reaction [resiquimod results in increased expression of IL6 protein]; [Protein Kinase Inhibitors results in decreased activity of IRAK4 protein] inhibits the reaction [resiquimod results in increased expression of IL6 protein] | PMID:28924041 | | ||||||||||||||||||||||
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