Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1590327
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tlr8
Name: toll-like receptor 8
Acc ID: CHEBI:36706
Term: resiquimod
Definition: An imidazoquinoline that has formula C17H22N4O2.
Chemical ID: MESH:C402365
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tlr8affects bindingISOTLR8 (Homo sapiens)6480464CTDresiquimod binds to TLR8 proteinPMID:15851485
Tlr8increases activityISOTLR8 (Homo sapiens)6480464CTDresiquimod results in increased activity of TLR8 proteinPMID:21398612
Tlr8increases activityISOTlr8 (Mus musculus)6480464CTDresiquimod results in increased activity of TLR8 proteinPMID:25780039
Tlr8multiple interactionsISOTLR8 (Homo sapiens)6480464CTDbafilomycin A1 inhibits the reaction [resiquimod results in increased activity of TLR8 protein]PMID:21398612
Go Back to source page   Continue to Ontology report