GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Il1b | increases expression | ISO | Il1b (Mus musculus) | 6480464 | CTD | Imiquimod results in increased expression of IL1B mRNA; Imiquimod results in increased expression of IL1B protein | PMID:31054998 PMID:36002070 | Il1b | increases expression | ISO | IL1B (Homo sapiens) | 6480464 | CTD | Imiquimod results in increased expression of IL1B mRNA | PMID:31383729 | Il1b | increases secretion | ISO | IL1B (Homo sapiens) | 6480464 | CTD | Imiquimod results in increased secretion of IL1B protein | PMID:18403674 PMID:31082466 PMID:31383729 PMID:34740670 | Il1b | multiple interactions | ISO | Il1b (Mus musculus) | 6480464 | CTD | [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Imiquimod] results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Imiquimod] results in increased secretion of IL1B protein; Chloroquine inhibits the reaction [Imiquimod results in increased expression of IL1B protein]; Chlorquinaldol inhibits the reaction [[Lipopolysaccharides co-treated with Imiquimod] results in increased secretion of IL1B protein]; ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL1B mRNA]; ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL1B protein]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Imiquimod] results in increased secretion of IL1B protein] | PMID:31054998 PMID:36002070 PMID:36577999 | Il1b | multiple interactions | ISO | IL1B (Homo sapiens) | 6480464 | CTD | [Dronabinol inhibits the reaction [Imiquimod results in increased activity of CASP1 protein]] which affects the localization of IL1B protein; Cannabidiol inhibits the reaction [Imiquimod results in increased secretion of IL1B protein]; Dronabinol inhibits the reaction [Imiquimod results in increased expression of IL1B mRNA]; Dronabinol inhibits the reaction [Imiquimod results in increased secretion of IL1B protein]; JHW 015 inhibits the reaction [Imiquimod results in increased secretion of IL1B protein] | PMID:31383729 PMID:34740670 | | ||||||||||||||||||||||
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