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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1559655
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il22ra1
Name: interleukin 22 receptor subunit alpha 1
Acc ID: CHEBI:36704
Term: imiquimod
Definition: An imidazoquinoline fused [4,5-c] carrying isobutyl and amino substituents at N-1 and C-4 respectively. A prescription medication, it acts as an immune response modifier and is used to treat genital warts, superficial basal cell carcinoma, and actinic keratosis.
Chemical ID: MESH:C056493
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il22ra1increases expressionISOIl22ra1 (Mus musculus)6480464CTDImiquimod results in increased expression of IL22RA1 mRNAPMID:31054998
Il22ra1multiple interactionsISOIl22ra1 (Mus musculus)6480464CTDferulic acid inhibits the reaction [Imiquimod results in increased expression of IL22RA1 mRNA]PMID:31054998
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