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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3554
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ren
Name: renin
Acc ID: CHEBI:3654
Term: chlorthalidone
Definition: An isoindole that has formula C14H11ClN2O4S.
Chemical ID: MESH:D002752
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Renincreases activityISORGD:7363666480464CTDChlorthalidone results in increased activity of REN protein

PMID:1116335, PMID:3319646
Renincreases expressionISORGD:7363666480464CTDChlorthalidone results in increased expression of REN protein modified form

PMID:796642
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.