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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732783
Species: Homo sapiens
RGD Object: Gene
Symbol: KL
Name: klotho
Acc ID: CHEBI:36489
Term: 17beta-estradiol 3-glucosiduronic acid
Definition: A steroid glucosiduronic acid that consists of 17beta-estradiol having a beta-glucuronyl residue attached at position 3 via a glycosidic linkage.
Chemical ID: MESH:C025482
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
KLincreases hydrolysisISOKl (Mus musculus)6480464CTDKL protein results in increased hydrolysis of estradiol-3-glucuronidePMID:14701853
KLmultiple interactionsISOKl (Mus musculus)6480464CTDestradiol-3-glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides]PMID:14701853
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