GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CYP1A2 | decreases methylation | EXP | | 6480464 | CTD | CYP1A2 protein results in decreased methylation of Chlorpromazine | PMID:20615392 | CYP1A2 | decreases response to substance | EXP | | 6480464 | CTD | CYP1A2 protein results in decreased susceptibility to Chlorpromazine | PMID:26477383 | CYP1A2 | increases oxidation | EXP | | 6480464 | CTD | CYP1A2 protein results in increased oxidation of Chlorpromazine | PMID:20615392 | CYP1A2 | multiple interactions | EXP | | 6480464 | CTD | [Chlorpromazine co-treated with Cholic Acids] affects the expression of CYP1A2 mRNA; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Chlorpromazine; Chlorpromazine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]; CYP1A2 protein results in increased metabolism of and results in increased activity of Chlorpromazine | PMID:18493746 PMID:19482014 PMID:23397584 PMID:27344345 | CYP1A2 | affects expression | ISO | Cyp1a2 (Rattus norvegicus) | 6480464 | CTD | Chlorpromazine affects the expression of CYP1A2 mRNA | PMID:18246545 | CYP1A2 | increases expression | ISO | Cyp1a2 (Rattus norvegicus) | 6480464 | CTD | Chlorpromazine results in increased expression of CYP1A2 mRNA | PMID:25596134 | |
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