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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736021
Species: Homo sapiens
RGD Object: Gene
Symbol: APP
Name: amyloid beta precursor protein
Acc ID: CHEBI:3638
Term: chloroquine
Definition: An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Chemical ID: MESH:D002738
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
APPaffects expressionISOApp (Rattus norvegicus)6480464CTDChloroquine affects the expression of APP mRNA; Chloroquine affects the expression of APP proteinPMID:9690670
APPaffects localizationISOApp (Rattus norvegicus)6480464CTDChloroquine affects the localization of APP proteinPMID:7715800
APPincreases expressionISOApp (Rattus norvegicus)6480464CTDChloroquine results in increased expression of APP proteinPMID:8616629
APPmultiple interactionsISOApp (Rattus norvegicus)6480464CTDChloroquine affects the localization of and affects the cleavage of APP proteinPMID:8787835
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