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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735183
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Map1lc3a
Name: microtubule-associated protein 1 light chain 3 alpha
Acc ID: CHEBI:3638
Term: chloroquine
Definition: An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Chemical ID: MESH:D002738
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map1lc3amultiple interactionsEXP 6480464CTDChloroquine inhibits the reaction [doramectin results in decreased expression of and results in increased lipidation of MAP1LC3A protein]; Chloroquine inhibits the reaction [doramectin results in decreased expression of MAP1LC3A protein]PMID:35137919
Map1lc3aincreases expressionISOMAP1LC3A (Homo sapiens)6480464CTDChloroquine results in increased expression of MAP1LC3A protein; Chloroquine results in increased expression of MAP1LC3A protein modified formPMID:30280407 PMID:30871063
Map1lc3amultiple interactionsISOMap1lc3a (Mus musculus)6480464CTDChloroquine affects the reaction [Cadmium Chloride results in increased expression of MAP1LC3A protein]PMID:35843418
Map1lc3amultiple interactionsISOMAP1LC3A (Homo sapiens)6480464CTDChloroquine inhibits the reaction [hydroquinone results in increased degradation of MAP1LC3A protein]PMID:35302183
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