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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:36108
Term: 1-hydroxy-2-naphthoic acid
Definition: A naphthoic acid with the carboxy group at position 2 and carrying a hydroxy substituent at the 1-position. It is a xenobiotic metabolite produced by the biodegradation of phenanthrene by microorganisms.
Chemical ID: MESH:C050175
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bmultiple interactionsISORGD:107906480464CTD1-hydroxy-2-naphthoic acid analog inhibits the reaction [lipopolysaccharide E coli O55-B5 results in increased expression of IL1B mRNA] 1-hydroxy-2-naphthoic acid analog inhibits the reaction [lipopolysaccharide E coli O55-B5 results in increased secretion of IL1B protein]

PMID:21667204
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