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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732503
Species: Mus musculus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen-activated protein kinase 1
Acc ID: CHEBI:35861
Term: dibenzo[a,l]pyrene
Definition: An ortho- and peri-fused polycyclic arene that has formula C24H14.
Chemical ID: MESH:C041517
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1multiple interactionsISOMapk1 (Rattus norvegicus)6480464CTDdibenzo(a,l)pyrene results in increased phosphorylation of and results in increased activity of MAPK1 protein; pifithrin inhibits the reaction [dibenzo(a,l)pyrene results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [dibenzo(a,l)pyrene results in increased phosphorylation of MAPK1 protein]PMID:16005925
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