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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731433
Species: Mus musculus
RGD Object: Gene
Symbol: Timp1
Name: tissue inhibitor of metalloproteinase 1
Acc ID: CHEBI:35807
Term: N-nitrosodimethylamine
Definition: A nitrosamine that has formula C2H6N2O.
Chemical ID: MESH:D004128
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Timp1increases expressionEXP 6480464CTDDimethylnitrosamine results in increased expression of TIMP1 mRNAPMID:16603200
Timp1multiple interactionsEXP 6480464CTDbicyclol inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP1 mRNA]PMID:16603200
Timp1increases expressionISOTIMP1 (Homo sapiens)6480464CTDDimethylnitrosamine results in increased expression of TIMP1 mRNAPMID:17547211
Timp1increases expressionISOTimp1 (Rattus norvegicus)6480464CTDDimethylnitrosamine results in increased expression of TIMP1 mRNA; Dimethylnitrosamine results in increased expression of TIMP1 proteinPMID:14600272 PMID:15067225 PMID:15339415 PMID:15504291 PMID:15504294 PMID:15571005 PMID:15723089 PMID:15890375 PMID:16169303 PMID:16270385 PMID:17036385 PMID:17432682 PMID:18371158 PMID:23485615 PMID:25380136 PMID:27009110
Timp1multiple interactionsISOTimp1 (Rattus norvegicus)6480464CTD2-phenyl-4-(3-pyridin-2-yl-1H-pyrazol-4-yl)pyridine inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP1 mRNA]; [Dietary Fats co-treated with Dimethylnitrosamine] results in increased expression of TIMP1 mRNA; [Silybin co-treated with Phosphatidylcholines co-treated with Vitamin E] inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP1 mRNA]; beta-amyrin inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP1 protein]; Drugs, Chinese Herbal inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP1 mRNA]; Drugs, Chinese Herbal inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP1 protein]; Flavonoids inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP1 protein]; pirfenidone inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP1 mRNA]; Plant Extracts inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP1 mRNA]; Plant Preparations inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP1 protein]; qishen yiqi inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP1 mRNA]; Valsartan inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP1 mRNA]PMID:15339415 PMID:15504291 PMID:15571005 PMID:15723089 PMID:16169303 PMID:16270385 PMID:17036385 PMID:17432682 PMID:18371158 PMID:23485615 PMID:27009110 PMID:32833043
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