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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621351
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Col1a2
Name: collagen type I alpha 2 chain
Acc ID: CHEBI:35807
Term: N-nitrosodimethylamine
Definition: A nitrosamine that has formula C2H6N2O.
Chemical ID: MESH:D004128
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDDimethylnitrosamine affects the expression of COL1A2 mRNA

PMID:16979622
increases expressionEXP 6480464CTDDimethylnitrosamine results in increased expression of COL1A2 mRNA

PMID:15723089, PMID:16604421, PMID:17724770, PMID:25380136
multiple interactionsEXP 6480464CTD2-phenyl-4-(3-pyridin-2-yl-1H-pyrazol-4-yl)pyridine inhibits the reaction [Dimethylnitrosamine results in increased expression of COL1A2 mRNA], Plant Preparations inhibits the reaction [Dimethylnitrosamine results in increased expression of COL1A2 mRNA], Silymarin inhibits the reaction [Dimethylnitrosamine results in increased expression of COL1A2 mRNA], Thalidomide inhibits the reaction [Dimethylnitrosamine results in increased expression of COL1A2 mRNA]

PMID:15723089, PMID:16604421, PMID:17724770
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.