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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2426
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Csf3
Name: colony stimulating factor 3
Acc ID: CHEBI:35807
Term: N-nitrosodimethylamine
Definition: A nitrosamine that has formula C2H6N2O.
Chemical ID: MESH:D004128
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7314166480464CTDCSF3 protein affects the reaction [Dimethylnitrosamine affects the expression of IL18 mRNA], CSF3 protein affects the reaction [Dimethylnitrosamine affects the expression of IL1A mRNA], CSF3 protein affects the reaction [Dimethylnitrosamine results in increased expression of IFNB1 mRNA], CSF3 protein affects the reaction [Dimethylnitrosamine results in increased expression of IL1R1 mRNA], CSF3 protein affects the reaction [Dimethylnitrosamine results in increased expression of TGFB1 mRNA], CSF3 protein inhibits the reaction [Dimethylnitrosamine results in increased expression of TNF mRNA], CSF3 protein promotes the reaction [Dimethylnitrosamine results in increased expression of IL1B mRNA], CSF3 protein promotes the reaction [Dimethylnitrosamine results in increased expression of IL6 mRNA]

PMID:17869372
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.