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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11329
Species: Mus musculus
RGD Object: Gene
Symbol: Sod1
Name: superoxide dismutase 1, soluble
Acc ID: CHEBI:35807
Term: N-nitrosodimethylamine
Definition: A nitrosamine that has formula C2H6N2O.
Chemical ID: MESH:D004128
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod1decreases expressionISOSod1 (Rattus norvegicus)6480464CTDDimethylnitrosamine results in decreased expression of SOD1 proteinPMID:14659978 PMID:15842777
Sod1multiple interactionsISOSod1 (Rattus norvegicus)6480464CTDEstradiol inhibits the reaction [Dimethylnitrosamine results in decreased expression of SOD1 protein]; ferric nitrilotriacetate inhibits the reaction [Dimethylnitrosamine results in decreased expression of SOD1 protein]; idoxifene inhibits the reaction [Dimethylnitrosamine results in decreased expression of SOD1 protein]PMID:14659978 PMID:15842777
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