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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737488
Species: Mus musculus
RGD Object: Gene
Symbol: Ifng
Name: interferon gamma
Acc ID: CHEBI:35696
Term: cobalt dichloride
Definition: A cobalt salt in which the cobalt metal is in the +2 oxidation state and the counter-anion is chloride. It is used as an indicator for water in desiccants.
Chemical ID: MESH:C018021
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ifngincreases expressionEXP 6480464CTDcobaltous chloride results in increased expression of IFNG proteinPMID:24218148
Ifngincreases secretionEXP 6480464CTDcobaltous chloride results in increased secretion of IFNG proteinPMID:22245253
Ifngmultiple interactionsEXP 6480464CTDcobaltous chloride promotes the reaction [[[TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; NOS2 protein promotes the reaction [cobaltous chloride promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]]PMID:8975779
Ifngmultiple interactionsISOIfng (Rattus norvegicus)6480464CTDcobaltous chloride inhibits the reaction [Oxygen deficiency results in increased expression of IFNG protein]PMID:18635243 PMID:19278353
Ifngmultiple interactionsISOIFNG (Homo sapiens)6480464CTD[cobaltous chloride co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNAPMID:29594315
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