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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733873
Species: Homo sapiens
RGD Object: Gene
Symbol: PLD2
Name: phospholipase D2
Acc ID: CHEBI:35696
Term: cobalt dichloride
Definition: A cobalt salt in which the cobalt metal is in the +2 oxidation state and the counter-anion is chloride. It is used as an indicator for water in desiccants.
Chemical ID: MESH:C018021
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PLD2increases activityEXP 6480464CTDcobaltous chloride results in increased activity of PLD2 proteinPMID:17640750
PLD2multiple interactionsEXP 6480464CTD2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [PLD2 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]]; Acetylcysteine inhibits the reaction [PLD2 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]]; PLD2 protein promotes the reaction [cobaltous chloride results in increased abundance of Dinoprostone]; PLD2 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]PMID:17640750
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