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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733100
Species: Homo sapiens
RGD Object: Gene
Symbol: BCL2
Name: BCL2 apoptosis regulator
Acc ID: CHEBI:35696
Term: cobalt dichloride
Definition: A cobalt salt in which the cobalt metal is in the +2 oxidation state and the counter-anion is chloride. It is used as an indicator for water in desiccants.
Chemical ID: MESH:C018021
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BCL2decreases expressionEXP 6480464CTDcobaltous chloride results in decreased expression of BCL2 mRNA; cobaltous chloride results in decreased expression of BCL2 proteinPMID:14741615 PMID:17786326
BCL2increases expressionEXP 6480464CTDcobaltous chloride results in increased expression of BCL2 proteinPMID:16827160
BCL2multiple interactionsEXP 6480464CTDcobaltous chloride inhibits the reaction [Cyclosporine results in decreased expression of BCL2 protein]; cobaltous chloride promotes the reaction [HIF1A protein results in increased expression of BCL2 mRNA]; HIPK2 protein inhibits the reaction [cobaltous chloride promotes the reaction [HIF1A protein results in increased expression of BCL2 mRNA]]; zinc chloride inhibits the reaction [cobaltous chloride results in decreased expression of BCL2 mRNA]; zinc chloride inhibits the reaction [cobaltous chloride results in decreased expression of BCL2 protein]; zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of BCL2 mRNA]PMID:17786326 PMID:19128456 PMID:19714248 PMID:22343435
BCL2decreases expressionISOBcl2 (Mus musculus)6480464CTDcobaltous chloride results in decreased expression of BCL2 mRNAPMID:24265542
BCL2decreases expressionISOBcl2 (Rattus norvegicus)6480464CTDcobaltous chloride results in decreased expression of BCL2 proteinPMID:19520152 PMID:30551423
BCL2multiple interactionsISOBcl2 (Mus musculus)6480464CTD[cobaltous chloride co-treated with 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole] results in decreased expression of BCL2 mRNAPMID:24265542
BCL2multiple interactionsISOBcl2 (Rattus norvegicus)6480464CTDPlant Extracts inhibits the reaction [cobaltous chloride results in decreased expression of BCL2 protein]PMID:30551423
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