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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731013
Species: Homo sapiens
RGD Object: Gene
Symbol: CCN2
Name: cellular communication network factor 2
Acc ID: CHEBI:35696
Term: cobalt dichloride
Definition: A cobalt salt in which the cobalt metal is in the +2 oxidation state and the counter-anion is chloride. It is used as an indicator for water in desiccants.
Chemical ID: MESH:C018021
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CCN2decreases expressionEXP 6480464CTDcobaltous chloride results in decreased expression of CCN2 mRNAPMID:19320972
CCN2increases expressionEXP 6480464CTDcobaltous chloride results in increased expression of CCN2 mRNAPMID:17034590 PMID:19376846
CCN2multiple interactionsEXP 6480464CTDcobaltous chloride promotes the reaction [HIF1A protein results in increased expression of CCN2 mRNA]; cobaltous chloride promotes the reaction [HIF1A protein results in increased expression of CCN2 protein]; cobaltous chloride promotes the reaction [TGFB1 protein results in increased expression of CCN2 mRNA]PMID:17034590
CCN2decreases expressionISOCcn2 (Rattus norvegicus)6480464CTDcobaltous chloride results in decreased expression of CCN2 mRNAPMID:24386269
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