A cobalt salt in which the cobalt metal is in the +2 oxidation state and the counter-anion is chloride. It is used as an indicator for water in desiccants.
Chemical ID:
MESH:C018021
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
2,2-bis(4-glycidyloxyphenyl)propane affects the reaction [[cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5 co-treated with Phloretin] results in increased expression of HIF1A mRNA]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [cobaltous chloride results in decreased expression of HIF1A protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; [cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5 co-treated with Phloretin] results in increased expression of HIF1A mRNA; cobaltous chloride inhibits the reaction [3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole results in increased expression of HIF1A mRNA]; cobaltous chloride promotes the reaction [[HIF1A protein binds to IL1B promoter] which results in increased expression of IL1B mRNA]; Echinomycin inhibits the reaction [cobaltous chloride results in increased activity of HIF1A protein]; HIF1A gene mutant form inhibits the reaction [cobaltous chloride affects the secretion of APLN protein]; HIF1A inhibits the reaction [cobaltous chloride results in increased expression of IL10 protein]; HIF1A inhibits the reaction [cobaltous chloride results in increased expression of IL4 protein]; HIF1A inhibits the reaction [cobaltous chloride results in increased expression of IL5 protein]; HIF1A promotes the reaction [cobaltous chloride results in increased expression of IL6 protein]; HIF1A promotes the reaction [cobaltous chloride results in increased expression of TNF protein]; HIF1A protein affects the reaction [cobaltous chloride results in increased expression of GAPDH mRNA]; HIF1A protein affects the reaction [cobaltous chloride results in increased expression of NDRG1 mRNA]; HIF1A protein promotes the reaction [cobaltous chloride promotes the reaction [GDF2 protein results in increased activity of ALPL protein]]; HIF1A protein promotes the reaction [cobaltous chloride results in increased expression of VEGFA protein]; Y 27632 promotes the reaction [cobaltous chloride affects the localization of HIF1A protein]
[cobaltous chloride results in increased expression of HIF1A protein] which results in increased expression of HMOX1 protein; [cobaltous chloride results in increased expression of HIF1A protein] which results in increased expression of MT1A protein; cobaltous chloride results in increased expression of HIF1A mRNA; cobaltous chloride results in increased expression of HIF1A protein
[cobaltous chloride co-treated with Diethylnitrosamine] results in increased expression of HIF1A protein; [cobaltous chloride co-treated with NGF protein] results in increased expression of HIF1A protein; [cobaltous chloride results in increased activity of HIF1A protein] which results in decreased susceptibility to 2-chloroethyl isocyanate; [cobaltous chloride results in increased activity of HIF1A protein] which results in decreased susceptibility to Carmustine; [cobaltous chloride results in increased activity of HIF1A protein] which results in decreased susceptibility to cyclohexylisocyanate; [cobaltous chloride results in increased activity of HIF1A protein] which results in decreased susceptibility to Hydrazines; [cobaltous chloride results in increased expression of and results in increased activity of HIF1A protein] which results in increased expression of EPO protein; [cobaltous chloride results in increased expression of and results in increased activity of HIF1A protein] which results in increased expression of VEGFA protein; [Cyclosporine co-treated with cobaltous chloride] results in increased expression of HIF1A protein; [Gentamicins co-treated with cobaltous chloride] results in increased expression of HIF1A protein; [monorden co-treated with cobaltous chloride] results in increased expression of HIF1A protein; [rhodioloside co-treated with cobaltous chloride co-treated with NGF protein] results in decreased expression of HIF1A mRNA; [Xanthine co-treated with XDH protein] inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; Cadmium Chloride inhibits the reaction [[cobaltous chloride results in increased activity of HIF1A protein] which results in decreased susceptibility to Hydrazines]; Cadmium Chloride inhibits the reaction [cobaltous chloride promotes the reaction [HIF1A protein binds to LOX promoter]]; Cadmium Chloride inhibits the reaction [cobaltous chloride results in increased activity of HIF1A protein]; Cadmium Chloride inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]; cobaltous chloride inhibits the reaction [methylmercuric chloride results in decreased expression of HIF1A protein]; cobaltous chloride inhibits the reaction [Methylmercury Compounds results in decreased expression of HIF1A protein]; cobaltous chloride promotes the reaction [[HIF1A protein co-treated with ARNT protein] results in increased expression of LOX mRNA]; cobaltous chloride promotes the reaction [fisetin results in increased activity of HIF1A protein]; cobaltous chloride promotes the reaction [HIF1A protein binds to LOX promoter]; cobaltous chloride promotes the reaction [HIF1A protein results in increased expression of LOX mRNA]; cobaltous chloride results in increased expression of and affects the localization of HIF1A protein; cobaltous chloride results in increased expression of and results in decreased degradation of and results in increased activity of HIF1A protein; cobaltous chloride results in increased expression of and results in increased activity of HIF1A protein; EPO protein inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; fisetin promotes the reaction [cobaltous chloride results in increased activity of HIF1A protein]; HIF1A mutant form inhibits the reaction [cobaltous chloride results in increased expression of LOX mRNA]; Plant Extracts inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]; R 59949 inhibits the reaction [rhodioloside promotes the reaction [cobaltous chloride results in increased expression of and affects the localization of HIF1A protein]]; rhodioloside inhibits the reaction [[cobaltous chloride co-treated with NGF protein] results in increased expression of HIF1A protein]; rhodioloside promotes the reaction [cobaltous chloride results in increased expression of and affects the localization of HIF1A protein]; Vitamin K 3 inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]
103D5R inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased activity of HIF1A protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased activity of HIF1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; 2-Methoxyestradiol inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; 4-(4-cyanophenyl)-2-(2-cyclopentylidenehydrazinyl)thiazole inhibits the reaction [cobaltous chloride results in increased expression of and results in increased localization of HIF1A protein]; 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; 8-bromocyclic GMP inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]; 8-bromocyclic GMP inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; [andrographolide co-treated with cobaltous chloride] results in increased hydroxylation of HIF1A protein; [cobaltous chloride co-treated with Glucose] promotes the reaction [HIF1A protein binds to EP300 protein]; [cobaltous chloride co-treated with Glucose] results in increased expression of and results in decreased ubiquitination of HIF1A protein; [cobaltous chloride co-treated with VEGFA protein] results in increased expression of HIF1A protein; [cobaltous chloride results in decreased abundance of Oxygen] which results in increased expression of HIF1A mRNA; [cobaltous chloride results in decreased abundance of Oxygen] which results in increased expression of HIF1A protein; [cobaltous chloride results in increased abundance of Cobalt] which results in increased expression of and results in decreased hydroxylation of HIF1A protein; [cobaltous chloride results in increased activity of SRC protein] promotes the reaction [[[HIF1A protein binds to STAT3 protein modified form] which binds to VEGFA promoter] binds to [APEX1 protein binds to CREBBP promoter]]; [cobaltous chloride results in increased activity of SRC protein] promotes the reaction [[HIF1A protein binds to STAT3 protein modified form] which binds to VEGFA promoter]; [cobaltous chloride results in increased activity of SRC protein] which results in increased expression of HIF1A protein; [cobaltous chloride results in increased expression of EPAS1 protein] which results in decreased expression of HIF1A protein; [cobaltous chloride results in increased expression of HIF1A protein] which results in decreased expression of EPAS1 protein; [Cycloheximide co-treated with cobaltous chloride] results in decreased expression of HIF1A protein; [Cyclosporine co-treated with cobaltous chloride] results in increased expression of HIF1A protein; [Gentamicins co-treated with cobaltous chloride] results in increased expression of HIF1A protein; [HIF1A protein results in increased susceptibility to cobaltous chloride] which results in increased expression of CD44 mRNA; [HIF1A protein results in increased susceptibility to cobaltous chloride] which results in increased expression of NANOG mRNA; [HIF1A protein results in increased susceptibility to cobaltous chloride] which results in increased expression of POU5F1 mRNA; [HIF1A protein results in increased susceptibility to cobaltous chloride] which results in increased expression of PROM1 mRNA; [HIF1A protein results in increased susceptibility to cobaltous chloride] which results in increased expression of SOX2 mRNA; [Wortmannin co-treated with U 0126] inhibits the reaction [IGF1 protein promotes the reaction [cobaltous chloride results in increased expression of HIF1A protein]]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; AG 1879 inhibits the reaction [[cobaltous chloride results in increased activity of SRC protein] which results in increased expression of HIF1A protein]; Amino Acids inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]; andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; Arsenic Trioxide promotes the reaction [cobaltous chloride results in increased expression of HIF1A protein]; Benzo(a)pyrene inhibits the reaction [cobaltous chloride affects the localization of HIF1A protein]; Benzo(a)pyrene inhibits the reaction [cobaltous chloride promotes the reaction [HIF1A protein binds to ARNT protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of HIF1A protein]]; Bilirubin inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]; Bilirubin inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; Cadmium Chloride inhibits the reaction [cobaltous chloride results in increased activity of HIF1A protein]; Cisplatin inhibits the reaction [cobaltous chloride results in increased activity of HIF1A protein]; clerodermic acid inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]; cobaltous chloride inhibits the reaction [Doxorubicin promotes the reaction [HIPK2 protein binds to HIF1A promoter]]; cobaltous chloride inhibits the reaction [HDAC1 protein binds to HIF1A promoter]; cobaltous chloride inhibits the reaction [HIPK2 protein binds to HIF1A promoter]; cobaltous chloride promotes the reaction [HIF1A protein binds to ARNT protein binds to EDN1 promoter]; cobaltous chloride promotes the reaction [HIF1A protein binds to ARNT protein]; cobaltous chloride promotes the reaction [HIF1A protein binds to CD36 promoter]; cobaltous chloride promotes the reaction [HIF1A protein binds to COL13A1 gene]; cobaltous chloride promotes the reaction [HIF1A protein binds to COL7A1 gene]; cobaltous chloride promotes the reaction [HIF1A protein binds to CXCL8 promoter]; cobaltous chloride promotes the reaction [HIF1A protein binds to HSP90AB1 protein]; cobaltous chloride promotes the reaction [HIF1A protein binds to MME gene]; cobaltous chloride promotes the reaction [HIF1A protein binds to VEGFA gene]; cobaltous chloride promotes the reaction [HIF1A protein results in increased expression of ABCB1 mRNA]; cobaltous chloride promotes the reaction [HIF1A protein results in increased expression of BCL2 mRNA]; cobaltous chloride promotes the reaction [HIF1A protein results in increased expression of CCN2 mRNA]; cobaltous chloride promotes the reaction [HIF1A protein results in increased expression of CCN2 protein]; cobaltous chloride promotes the reaction [HIF1A protein results in increased expression of EPO mRNA]; cobaltous chloride promotes the reaction [TP53 protein mutant form binds to [HIF1A protein binds to ARNT protein]]; cobaltous chloride promotes the reaction [TP53 protein mutant form binds to HIF1A protein]; cobaltous chloride results in decreased degradation of and results in increased activity of HIF1A protein; cobaltous chloride results in increased expression of and affects the localization of HIF1A protein; cobaltous chloride results in increased expression of and results in increased activity of HIF1A protein; cobaltous chloride results in increased expression of and results in increased localization of HIF1A protein; cobaltous chloride results in increased expression of and results in increased secretion of HIF1A protein; Cycloheximide inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of HIF1A protein]; Cyclosporine inhibits the reaction [cobaltous chloride results in increased activity of HIF1A protein]; dihydrotanshinone I inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; DUSP10 protein promotes the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]]; epoxomicin inhibits the reaction [scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of HIF1A protein]]; Flavanones inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; Folic Acid inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; geldanamycin inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; Genistein affects the reaction [cobaltous chloride promotes the reaction [HIF1A protein binds to ARNT protein binds to EDN1 promoter]]; Glutathione Disulfide analog promotes the reaction [cobaltous chloride results in increased activity of HIF1A protein]; HIF1A mutant form inhibits the reaction [cobaltous chloride results in increased expression of BNIP3 mRNA]; HIF1A mutant form inhibits the reaction [cobaltous chloride results in increased expression of IGF2 mRNA]; HIF1A protein affects the reaction [cobaltous chloride results in decreased expression of S100A1 protein]; HIF1A protein affects the reaction [cobaltous chloride results in increased expression of DDIT4 mRNA]; HIF1A protein affects the reaction [cobaltous chloride results in increased expression of HIF1A protein]; HIF1A protein affects the reaction [cobaltous chloride results in increased expression of VEGFA mRNA]; HIF1A protein promotes the reaction [cobaltous chloride promotes the reaction [TP53 protein mutant form binds to COL7A1 gene]]; HIF1A protein promotes the reaction [cobaltous chloride results in decreased expression of MME mRNA]; HIF1A protein promotes the reaction [cobaltous chloride results in decreased expression of MME protein]; HIF1A protein promotes the reaction [cobaltous chloride results in increased expression of EPO mRNA]; HIF1A protein promotes the reaction [SP1 protein promotes the reaction [cobaltous chloride results in increased expression of DDIT4]]; HIPK2 protein inhibits the reaction [cobaltous chloride promotes the reaction [HIF1A protein results in increased expression of ABCB1 mRNA]]; HIPK2 protein inhibits the reaction [cobaltous chloride promotes the reaction [HIF1A protein results in increased expression of BCL2 mRNA]]; HIPK2 protein inhibits the reaction [cobaltous chloride promotes the reaction [HIF1A protein results in increased expression of EPO mRNA]]; HIPK2 protein inhibits the reaction [cobaltous chloride results in decreased degradation of and results in increased activity of HIF1A protein]; HMOX1 protein affects the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]]; IGF1 protein promotes the reaction [cobaltous chloride results in increased expression of HIF1A protein]; Indican inhibits the reaction [cobaltous chloride affects the localization of HIF1A protein]; L-4F peptide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; L-4F peptide promotes the reaction [[Cycloheximide co-treated with cobaltous chloride] results in decreased expression of HIF1A protein]; Mercuric Chloride inhibits the reaction [cobaltous chloride results in increased activity of HIF1A protein]; MG 262 inhibits the reaction [scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of HIF1A protein]]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; NAT10 affects the reaction [cobaltous chloride results in increased expression of HIF1A protein]; NFE2L2 protein affects the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]]; NG-Nitroarginine Methyl Ester inhibits the reaction [Folic Acid inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]]; Nitroprusside inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; PDK4 protein affects the reaction [cobaltous chloride results in increased expression of HIF1A protein]; peoniflorin inhibits the reaction [[cobaltous chloride results in decreased abundance of Oxygen] which results in increased expression of HIF1A mRNA]; peoniflorin inhibits the reaction [[cobaltous chloride results in decreased abundance of Oxygen] which results in increased expression of HIF1A protein]; peptide 5F inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; plastochromanol 8 inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; PTEN protein inhibits the reaction [cobaltous chloride results in increased activity of HIF1A protein]; PTGES protein promotes the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]; R 59949 inhibits the reaction [cobaltous chloride results in increased activity of HIF1A protein]; R 59949 inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; Reactive Oxygen Species affects the reaction [cobaltous chloride results in increased expression of HIF1A protein]; Resveratrol inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; rhein inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; romidepsin inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; sauchinone inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; SB 203580 inhibits the reaction [cobaltous chloride results in increased activity of HIF1A protein]; SB 203580 inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]; SB 203580 inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose co-treated with Cycloheximide] results in decreased expression of HIF1A protein]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] promotes the reaction [HIF1A protein binds to EP300 protein]]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of and results in decreased ubiquitination of HIF1A protein]; scutellarin promotes the reaction [Cycloheximide inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of HIF1A protein]]; SIRT1 protein promotes the reaction [Resveratrol inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]]; tetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased activity of HIF1A protein]; tetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of and affects the localization of HIF1A protein]; TP53 gene mutant form promotes the reaction [cobaltous chloride results in increased expression of HIF1A protein]; tricarbonyldichlororuthenium (II) dimer inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]; tricarbonyldichlororuthenium (II) dimer inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; U 0126 inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; Vanadates inhibits the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]]; Vanadates inhibits the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]]; Wortmannin inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; zinc chloride inhibits the reaction [cobaltous chloride inhibits the reaction [Doxorubicin promotes the reaction [HIPK2 protein binds to HIF1A promoter]]]; zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; ZM323881 inhibits the reaction [[cobaltous chloride co-treated with VEGFA protein] results in increased expression of HIF1A protein]
