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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621619
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Keap1
Name: Kelch-like ECH-associated protein 1
Acc ID: CHEBI:35696
Term: cobalt dichloride
Definition: A cobalt salt in which the cobalt metal is in the +2 oxidation state and the counter-anion is chloride. It is used as an indicator for water in desiccants.
Chemical ID: MESH:C018021
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Keap1increases expressionEXP 6480464CTDcobaltous chloride results in increased expression of KEAP1 mRNAPMID:24386269
Keap1affects response to substanceISOKEAP1 (Homo sapiens)6480464CTDKEAP1 protein affects the susceptibility to cobaltous chloridePMID:29966676
Keap1multiple interactionsISOKEAP1 (Homo sapiens)6480464CTDKEAP1 protein inhibits the reaction [cobaltous chloride results in increased expression of GCLC mRNA]; KEAP1 protein inhibits the reaction [cobaltous chloride results in increased expression of GCLM mRNA]; KEAP1 protein inhibits the reaction [cobaltous chloride results in increased expression of NQO1 mRNA]; KEAP1 protein promotes the reaction [cobaltous chloride results in increased expression of HMOX1 mRNA]PMID:29966676
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