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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2153
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Arnt
Name: aryl hydrocarbon receptor nuclear translocator
Acc ID: CHEBI:35696
Term: cobalt dichloride
Definition: A cobalt salt in which the cobalt metal is in the +2 oxidation state and the counter-anion is chloride. It is used as an indicator for water in desiccants.
Chemical ID: MESH:C018021
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDcobaltous chloride results in increased expression of ARNT protein

PMID:10559391
multiple interactionsEXP 6480464CTDcobaltous chloride promotes the reaction [[HIF1A protein co-treated with ARNT protein] results in increased expression of LOX mRNA]

PMID:23161664
affects localizationISORGD:7327396480464CTDcobaltous chloride affects the localization of ARNT protein

PMID:25826687, PMID:26350169
increases expressionISORGD:7327396480464CTDcobaltous chloride results in increased expression of ARNT mRNA

PMID:29960020
multiple interactionsISORGD:101896480464CTDARNT affects the reaction [cobaltous chloride results in increased expression of HMOX1 mRNA], ARNT affects the reaction [cobaltous chloride results in increased expression of SLC2A1 mRNA]

PMID:11043581
multiple interactionsISORGD:7327396480464CTDARNT gene mutant form inhibits the reaction [cobaltous chloride results in increased expression of CA9 mRNA], ARNT gene mutant form inhibits the reaction [cobaltous chloride results in increased expression of VEGFA mRNA], ARNT protein promotes the reaction [cobaltous chloride deficiency results in increased expression of COL7A1 mRNA], ARNT protein promotes the reaction [cobaltous chloride deficiency results in increased expression of LAMC2 mRNA], Benzo(a)pyrene inhibits the reaction [cobaltous chloride promotes the reaction [HIF1A protein binds to ARNT protein]], cobaltous chloride promotes the reaction [[AHR protein binds to ARNT protein] which binds to CYP1A1 promoter], cobaltous chloride promotes the reaction [HIF1A protein binds to ARNT protein binds to EDN1 promoter], cobaltous chloride promotes the reaction [HIF1A protein binds to ARNT protein], cobaltous chloride promotes the reaction [TP53 protein mutant form binds to [HIF1A protein binds to ARNT protein]], Genistein affects the reaction [cobaltous chloride promotes the reaction [HIF1A protein binds to ARNT protein binds to EDN1 promoter]]

PMID:10939628, PMID:17599377, PMID:20228066, PMID:24299737, PMID:30381462
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.