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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1311417
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Col7a1
Name: collagen type VII alpha 1 chain
Acc ID: CHEBI:35696
Term: cobalt dichloride
Definition: A cobalt salt in which the cobalt metal is in the +2 oxidation state and the counter-anion is chloride. It is used as an indicator for water in desiccants.
Chemical ID: MESH:C018021
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:13228696480464CTDARNT protein promotes the reaction [cobaltous chloride deficiency results in increased expression of COL7A1 mRNA], cobaltous chloride promotes the reaction [[SMARCA4 protein binds to SMARCA2 protein] which binds to COL7A1 gene], cobaltous chloride promotes the reaction [HIF1A protein binds to COL7A1 gene], cobaltous chloride promotes the reaction [SMARCA4 protein binds to COL7A1 gene], cobaltous chloride promotes the reaction [TP53 protein mutant form binds to COL7A1 gene], HIF1A protein promotes the reaction [cobaltous chloride promotes the reaction [TP53 protein mutant form binds to COL7A1 gene]]

PMID:30381462
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.