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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737571
Species: Homo sapiens
RGD Object: Gene
Symbol: HMGCS2
Name: 3-hydroxy-3-methylglutaryl-CoA synthase 2
Acc ID: CHEBI:35591
Term: pregnenolone 16alpha-carbonitrile
Definition: An aliphatic nitrile that has formula C22H31NO2.
Chemical ID: MESH:D011285
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HMGCS2decreases expressionISOHmgcs2 (Mus musculus)6480464CTDPregnenolone Carbonitrile results in decreased expression of HMGCS2 mRNAPMID:28903501
HMGCS2multiple interactionsISOHmgcs2 (Mus musculus)6480464CTDPregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of HMGCS2 mRNA]PMID:20359477
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