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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69210
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP7A1
Name: cytochrome P450 family 7 subfamily A member 1
Acc ID: CHEBI:35591
Term: pregnenolone 16alpha-carbonitrile
Definition: An aliphatic nitrile that has formula C22H31NO2.
Chemical ID: MESH:D011285
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP7A1decreases expressionISOCyp7a1 (Mus musculus)6480464CTDPregnenolone Carbonitrile results in decreased expression of CYP7A1 mRNAPMID:15629111 PMID:22982774 PMID:27413110 PMID:28903501
CYP7A1decreases expressionISOCyp7a1 (Rattus norvegicus)6480464CTDPregnenolone Carbonitrile results in decreased expression of CYP7A1 mRNAPMID:19162173
CYP7A1multiple interactionsISOCyp7a1 (Mus musculus)6480464CTDPregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of CYP7A1 mRNA]PMID:20359477
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