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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1349768
Species: Homo sapiens
RGD Object: Gene
Symbol: GSTM3
Name: glutathione S-transferase mu 3
Acc ID: CHEBI:35591
Term: pregnenolone 16alpha-carbonitrile
Definition: An aliphatic nitrile that has formula C22H31NO2.
Chemical ID: MESH:D011285
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GSTM3increases expressionISOGstm5 (Mus musculus)6480464CTDPregnenolone Carbonitrile results in increased expression of GSTM3 mRNAPMID:18723825 PMID:22496397 PMID:27413110 PMID:28903501
GSTM3multiple interactionsISOGstm5 (Mus musculus)6480464CTD[Pregnenolone Carbonitrile results in increased activity of NR1I2 protein] which results in increased expression of GSTM3 mRNA; NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of GSTM3 mRNA]PMID:22496397
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