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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1552629
Species: Mus musculus
RGD Object: Gene
Symbol: Nr1i3
Name: nuclear receptor subfamily 1, group I, member 3
Acc ID: CHEBI:3558
Term: cerivastatin
Definition: (3R,5S)-3,5-dihydroxyhept-6-enoic acid in which the (7E)-hydrogen is substituted by a 4-(4-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)pyridin-3-yl group. Formerly used (as its sodium salt) to lower cholesterol and prevent cardiovascular disease, it was withdrawn from the market worldwide in 2001 following reports of a severe form of muscle toxicity.
Chemical ID: MESH:C086276
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i3increases activityEXP 6480464CTDcerivastatin results in increased activity of NR1I3 proteinPMID:15802384
Nr1i3decreases activityISONR1I3 (Homo sapiens)6480464CTDcerivastatin results in decreased activity of NR1I3 protein alternative formPMID:21778469
Nr1i3increases activityISONR1I3 (Homo sapiens)6480464CTDcerivastatin results in increased activity of NR1I3 proteinPMID:15802384
Nr1i3increases activityISONr1i3 (Rattus norvegicus)6480464CTDcerivastatin results in increased activity of NR1I3 proteinPMID:15802384
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