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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737416
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP2C19
Name: cytochrome P450 family 2 subfamily C member 19
Acc ID: CHEBI:35549
Term: perfluorooctanoic acid
Definition: A fluoroalkanoic acid that is perfluorinated octanoic acid.
Chemical ID: MESH:C023036
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP2C19decreases activityEXP 6480464CTDperfluorooctanoic acid results in decreased activity of CYP2C19 proteinPMID:31809754 PMID:35121066
CYP2C19decreases expressionEXP 6480464CTDperfluorooctanoic acid results in decreased expression of CYP2C19 mRNAPMID:31809754
CYP2C19increases expressionEXP 6480464CTDperfluorooctanoic acid results in increased expression of CYP2C19 mRNAPMID:37302725
CYP2C19increases expressionISOCyp2c6 (Rattus norvegicus)6480464CTDperfluorooctanoic acid results in increased expression of CYP2C6V1 mRNAPMID:21723365 PMID:28511854
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