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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737102
Species: Homo sapiens
RGD Object: Gene
Symbol: COMT
Name: catechol-O-methyltransferase
Acc ID: CHEBI:35549
Term: perfluorooctanoic acid
Definition: A fluoroalkanoic acid that is perfluorinated octanoic acid.
Chemical ID: MESH:C023036
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
COMTincreases expressionEXP 6480464CTDperfluorooctanoic acid results in increased expression of COMT mRNAPMID:33772556
COMTdecreases expressionISOComt (Mus musculus)6480464CTDperfluorooctanoic acid results in decreased expression of COMT mRNAPMID:20118188 PMID:23626681
COMTmultiple interactionsISOComt (Mus musculus)6480464CTD[perfluorooctanoic acid co-treated with Dietary Fats, Unsaturated] results in decreased expression of COMT mRNA; PPARA promotes the reaction [perfluorooctanoic acid results in increased expression of COMT mRNA]PMID:20118188 PMID:23626681
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