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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736050
Species: Mus musculus
RGD Object: Gene
Symbol: Gpx4
Name: glutathione peroxidase 4
Acc ID: CHEBI:35549
Term: perfluorooctanoic acid
Definition: A fluoroalkanoic acid that is perfluorinated octanoic acid.
Chemical ID: MESH:C023036
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDperfluorooctanoic acid affects the expression of GPX4 mRNA

PMID:18281256
increases expressionISORGD:7360496480464CTDperfluorooctanoic acid results in increased expression of GPX4 protein

PMID:26879310
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.