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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735631
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP11A1
Name: cytochrome P450 family 11 subfamily A member 1
Acc ID: CHEBI:35549
Term: perfluorooctanoic acid
Definition: A fluoroalkanoic acid that is perfluorinated octanoic acid.
Chemical ID: MESH:C023036
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP11A1decreases expressionEXP 6480464CTDperfluorooctanoic acid results in decreased expression of CYP11A1 mRNAPMID:21641976
CYP11A1decreases expressionISOCyp11a1 (Mus musculus)6480464CTDperfluorooctanoic acid results in decreased expression of CYP11A1 mRNA; perfluorooctanoic acid results in decreased expression of CYP11A1 proteinPMID:21712084 PMID:22414604 PMID:28219760 PMID:29721586 PMID:35104888
CYP11A1multiple interactionsISOCyp11a1 (Mus musculus)6480464CTDPPARA gene mutant form inhibits the reaction [perfluorooctanoic acid results in decreased expression of CYP11A1 protein]; SERPINA6 protein inhibits the reaction [perfluorooctanoic acid results in decreased expression of CYP11A1 protein]PMID:22414604 PMID:29721586
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