GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Pcna | decreases expression | EXP | | 6480464 | CTD | perfluorooctanoic acid results in decreased expression of PCNA protein | PMID:22414604 | Pcna | increases expression | EXP | | 6480464 | CTD | perfluorooctanoic acid results in increased expression of PCNA mRNA; perfluorooctanoic acid results in increased expression of PCNA protein | PMID:20118188 PMID:21499893 | Pcna | multiple interactions | EXP | | 6480464 | CTD | Estradiol inhibits the reaction [perfluorooctanoic acid results in decreased expression of PCNA protein]; Estradiol promotes the reaction [Progesterone inhibits the reaction [perfluorooctanoic acid results in decreased expression of PCNA protein]]; Progesterone inhibits the reaction [perfluorooctanoic acid results in decreased expression of PCNA protein]; Progesterone promotes the reaction [Estradiol inhibits the reaction [perfluorooctanoic acid results in decreased expression of PCNA protein]] | PMID:22414604 | Pcna | decreases expression | ISO | PCNA (Homo sapiens) | 6480464 | CTD | perfluorooctanoic acid results in decreased expression of PCNA mRNA; perfluorooctanoic acid results in decreased expression of PCNA protein | PMID:26879310 PMID:32790152 PMID:36326898 | |
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