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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727780
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gpx2
Name: glutathione peroxidase 2
Acc ID: CHEBI:35549
Term: perfluorooctanoic acid
Definition: A fluoroalkanoic acid that is perfluorinated octanoic acid.
Chemical ID: MESH:C023036
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gpx2increases expressionISOGPX2 (Homo sapiens)6480464CTDperfluorooctanoic acid results in increased expression of GPX2 mRNAPMID:37302725
Gpx2increases expressionISOGpx2 (Mus musculus)6480464CTDperfluorooctanoic acid results in increased expression of GPX2 mRNAPMID:20118188
Gpx2multiple interactionsISOGpx2 (Mus musculus)6480464CTD[perfluorooctanoic acid co-treated with Dietary Fats, Unsaturated] results in increased expression of GPX2 mRNA; PPARA promotes the reaction [perfluorooctanoic acid results in decreased expression of GPX2 mRNA]PMID:20118188 PMID:23626681
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