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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70373
Species: Homo sapiens
RGD Object: Gene
Symbol: BAX
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:35549
Term: perfluorooctanoic acid
Definition: A fluoroalkanoic acid that is perfluorinated octanoic acid.
Chemical ID: MESH:C023036
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BAXaffects expressionEXP 6480464CTDperfluorooctanoic acid affects the expression of BAX mRNAPMID:32068100
BAXincreases expressionEXP 6480464CTDperfluorooctanoic acid results in increased expression of BAX mRNA; perfluorooctanoic acid results in increased expression of BAX proteinPMID:32790152 PMID:32971237 PMID:34765786 PMID:35123991
BAXmultiple interactionsEXP 6480464CTD[perfluorooctanoic acid co-treated with Carbenoxolone] results in increased expression of BAX protein; Tretinoin inhibits the reaction [perfluorooctanoic acid results in increased expression of BAX protein]PMID:32971237
BAXincreases expressionISOBax (Mus musculus)6480464CTDperfluorooctanoic acid results in increased expression of BAX mRNA; perfluorooctanoic acid results in increased expression of BAX proteinPMID:28219760 PMID:35066053 PMID:37044272
BAXincreases expressionISOBax (Rattus norvegicus)6480464CTDperfluorooctanoic acid results in increased expression of BAX mRNAPMID:19162173 PMID:21318169
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