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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3757
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Srd5a1
Name: steroid 5 alpha-reductase 1
Acc ID: CHEBI:35549
Term: perfluorooctanoic acid
Definition: A fluoroalkanoic acid that is perfluorinated octanoic acid.
Chemical ID: MESH:C023036
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityEXP 6480464CTDperfluorooctanoic acid results in decreased activity of SRD5A1 protein

PMID:28535922
decreases expressionEXP 6480464CTDperfluorooctanoic acid results in decreased expression of SRD5A1 mRNA

PMID:19162173
decreases expressionISORGD:113416480464CTDperfluorooctanoic acid results in decreased expression of SRD5A1 mRNA

PMID:17681415, PMID:23626681
multiple interactionsISORGD:113416480464CTD[perfluorooctanoic acid co-treated with Dietary Fats, Unsaturated] results in decreased expression of SRD5A1 mRNA

PMID:23626681
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.