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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345262
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP51A1
Name: cytochrome P450 family 51 subfamily A member 1
Acc ID: CHEBI:35549
Term: perfluorooctanoic acid
Definition: A fluoroalkanoic acid that is perfluorinated octanoic acid.
Chemical ID: MESH:C023036
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP51A1decreases expressionEXP 6480464CTDperfluorooctanoic acid results in decreased expression of CYP51A1 proteinPMID:26879310
CYP51A1increases expressionEXP 6480464CTDperfluorooctanoic acid results in increased expression of CYP51A1 mRNAPMID:23978341 PMID:25868421 PMID:36326898
CYP51A1affects expressionISOCyp51 (Mus musculus)6480464CTDperfluorooctanoic acid affects the expression of CYP51 mRNAPMID:19429403
CYP51A1decreases expressionISOCyp51 (Rattus norvegicus)6480464CTDperfluorooctanoic acid results in decreased expression of CYP51 mRNA; perfluorooctanoic acid results in decreased expression of CYP51 proteinPMID:19162173 PMID:34958885
CYP51A1decreases expressionISOCyp51 (Mus musculus)6480464CTDperfluorooctanoic acid results in decreased expression of CYP51A1 mRNAPMID:30508572
CYP51A1increases expressionISOCyp51 (Mus musculus)6480464CTDperfluorooctanoic acid results in increased expression of CYP51A1 mRNAPMID:17681415
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