GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Hsd3b1 | affects expression | ISO | Hsd3b1 (Mus musculus) | 6480464 | CTD | perfluorooctanoic acid affects the expression of HSD3B1 mRNA | PMID:21712084 | Hsd3b1 | decreases expression | ISO | Hsd3b1 (Mus musculus) | 6480464 | CTD | perfluorooctanoic acid results in decreased expression of HSD3B1 mRNA; perfluorooctanoic acid results in decreased expression of HSD3B1 protein | PMID:17681415 PMID:22414604 PMID:28219760 PMID:35104888 | Hsd3b1 | increases expression | ISO | Hsd3b1 (Mus musculus) | 6480464 | CTD | perfluorooctanoic acid results in increased expression of HSD3B1 protein | PMID:20118188 | Hsd3b1 | multiple interactions | ISO | Hsd3b1 (Mus musculus) | 6480464 | CTD | PPARA affects the reaction [perfluorooctanoic acid affects the expression of HSD3B1 mRNA]; PPARA gene mutant form inhibits the reaction [perfluorooctanoic acid results in decreased expression of HSD3B1 protein]; PPARA promotes the reaction [perfluorooctanoic acid results in increased expression of HSD3B1 protein] | PMID:20118188 PMID:21712084 PMID:22414604 | Hsd3b1 | multiple interactions | ISO | HSD3B1 (Homo sapiens) | 6480464 | CTD | [perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased expression of HSD3B1 mRNA; [perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased expression of HSD3B1 protein; STF-31 inhibits the reaction [[perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased expression of HSD3B1 protein] | PMID:34311058 | | ||||||||||||||||||||||
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