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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11250
Species: Mus musculus
RGD Object: Gene
Symbol: Rxra
Name: retinoid X receptor alpha
Acc ID: CHEBI:35549
Term: perfluorooctanoic acid
Definition: A fluoroalkanoic acid that is perfluorinated octanoic acid.
Chemical ID: MESH:C023036
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rxraincreases response to substanceEXP 6480464CTDRXRA protein results in increased susceptibility to perfluorooctanoic acidPMID:17259670
Rxramultiple interactionsEXP 6480464CTDperfluorooctanoic acid binds to and results in increased activity of RXRA proteinPMID:16731579
Rxraincreases expressionISORXRA (Homo sapiens)6480464CTDperfluorooctanoic acid results in increased expression of RXRA mRNAPMID:36326898
Rxramultiple interactionsISORXRA (Homo sapiens)6480464CTD[PPARA co-treated with perfluorooctanoic acid] results in increased expression of RXRA mRNAPMID:19751795
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