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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736390
Species: Homo sapiens
RGD Object: Gene
Symbol: PPBP
Name: pro-platelet basic protein
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PPBPdecreases expressionEXP 6480464CTDCadmium Chloride results in decreased expression of PPBP mRNAPMID:26472689
PPBPdecreases secretionEXP 6480464CTDCadmium Chloride results in decreased secretion of PPBP proteinPMID:26138014
PPBPmultiple interactionsEXP 6480464CTDAcetylcysteine promotes the reaction [Cadmium Chloride results in decreased secretion of PPBP protein]PMID:26138014
PPBPincreases expressionISOPpbp (Rattus norvegicus)6480464CTDCadmium Chloride results in increased expression of PPBP mRNAPMID:17327700
PPBPincreases methylationISOPpbp (Rattus norvegicus)6480464CTDCadmium Chloride results in increased methylation of PPBP promoterPMID:22457795
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