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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736066
Species: Homo sapiens
RGD Object: Gene
Symbol: SPP1
Name: secreted phosphoprotein 1
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SPP1decreases expressionEXP 6480464CTDCadmium Chloride results in decreased expression of SPP1 mRNAPMID:22019892
SPP1increases expressionEXP 6480464CTDCadmium Chloride results in increased expression of SPP1 mRNAPMID:17547211
SPP1multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in decreased expression of SPP1 mRNA]; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SPP1 mRNAPMID:22019892 PMID:29741670
SPP1increases exportISOSpp1 (Rattus norvegicus)6480464CTDCadmium Chloride results in increased export of SPP1 proteinPMID:29421648
SPP1increases expressionISOSpp1 (Rattus norvegicus)6480464CTDCadmium Chloride results in increased expression of SPP1 mRNA; Cadmium Chloride results in increased expression of SPP1 proteinPMID:17327700 PMID:26815315
SPP1increases methylationISOSpp1 (Rattus norvegicus)6480464CTDCadmium Chloride results in increased methylation of SPP1 promoterPMID:22457795
SPP1multiple interactionsISOSpp1 (Mus musculus)6480464CTD[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of SPP1 mRNA; [Tetradecanoylphorbol Acetate co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] affects the expression of SPP1 mRNAPMID:19840844 PMID:31904401
SPP1multiple interactionsISOSpp1 (Rattus norvegicus)6480464CTDCurcumin inhibits the reaction [Cadmium Chloride results in increased export of SPP1 protein]PMID:29421648
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