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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736050
Species: Mus musculus
RGD Object: Gene
Symbol: Gpx4
Name: glutathione peroxidase 4
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gpx4increases expressionEXP 6480464CTDCadmium Chloride results in increased expression of GPX4 mRNAPMID:17499415
Gpx4decreases expressionISOGpx4 (Rattus norvegicus)6480464CTDCadmium Chloride results in decreased expression of GPX4 mRNAPMID:20643113
Gpx4multiple interactionsISOGpx4 (Rattus norvegicus)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of GPX4 mRNA; MIR34A mRNA affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of GPX4 mRNA]; Sodium Selenite inhibits the reaction [Cadmium Chloride results in decreased expression of GPX4 mRNA]PMID:20643113 PMID:34558789
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