GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | APP | multiple interactions | EXP | | 6480464 | CTD | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of APP mRNA | PMID:29741670 | APP | increases expression | ISO | App (Mus musculus) | 6480464 | CTD | Cadmium Chloride results in increased expression of APP protein; Cadmium Chloride results in increased expression of APP protein modified form | PMID:26026611 PMID:27377441 PMID:30213552 | APP | multiple interactions | ISO | App (Rattus norvegicus) | 6480464 | CTD | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of APP protein modified form; Triiodothyronine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of APP protein modified form] | PMID:36868496 | APP | multiple interactions | ISO | App (Mus musculus) | 6480464 | CTD | [[Cadmium Chloride results in decreased activity of CHRM1 protein] which affects the expression of ACHE mRNA alternative form] which results in increased expression of APP protein modified form; [Cadmium Chloride results in decreased activity of CHRM1 protein] which results in increased expression of APP protein modified form; [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of APP mRNA; ACHE mRNA promotes the reaction [Cadmium Chloride results in increased expression of APP protein modified form]; APP mutant form inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein]; APP mutant form inhibits the reaction [Cadmium Chloride results in increased activity of CASP7 protein]; CHRM1 mRNA inhibits the reaction [Cadmium Chloride results in increased expression of APP protein modified form]; HSF1 protein inhibits the reaction [Cadmium Chloride results in increased expression of APP protein]; HSPB2 protein inhibits the reaction [Cadmium Chloride results in increased expression of APP protein] | PMID:19840844 PMID:26026611 PMID:27377441 PMID:30213552 | | ||||||||||||||||||||||
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