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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732969
Species: Mus musculus
RGD Object: Gene
Symbol: Xrcc1
Name: X-ray repair complementing defective repair in Chinese hamster cells 1
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Xrcc1decreases expressionISOXRCC1 (Homo sapiens)6480464CTDCadmium Chloride results in decreased expression of XRCC1 mRNA; Cadmium Chloride results in decreased expression of XRCC1 proteinPMID:22112500 PMID:26472689
Xrcc1increases methylationISOXRCC1 (Homo sapiens)6480464CTDCadmium Chloride results in increased methylation of XRCC1 promoterPMID:22112500
Xrcc1multiple interactionsISOXRCC1 (Homo sapiens)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of XRCC1 mRNA; [Cadmium Chloride results in increased activity of [DNMT1 protein co-treated with DNMT3A protein]] which results in decreased expression of XRCC1 mRNA; [Cadmium Chloride results in increased activity of [DNMT1 protein co-treated with DNMT3A protein]] which results in increased methylation of XRCC1 promoter; Decitabine inhibits the reaction [Cadmium Chloride results in decreased expression of XRCC1 mRNA]; Decitabine inhibits the reaction [Cadmium Chloride results in decreased expression of XRCC1 protein]PMID:22112500 PMID:35301059
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