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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732299
Species: Mus musculus
RGD Object: Gene
Symbol: Fbxo6
Name: F-box protein 6
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fbxo6decreases expressionEXP 6480464CTDCadmium Chloride results in decreased expression of FBXO6 mRNAPMID:20061341
Fbxo6decreases expressionISOFbxo6 (Rattus norvegicus)6480464CTDCadmium Chloride results in decreased expression of FBXO6 mRNAPMID:33453195
Fbxo6decreases response to substanceISOFBXO6 (Homo sapiens)6480464CTDFBXO6 protein results in decreased susceptibility to Cadmium ChloridePMID:25374377
Fbxo6multiple interactionsISOFBXO6 (Homo sapiens)6480464CTDFBXO6 protein inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 protein]; FBXO6 protein inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 protein]; FBXO6 protein inhibits the reaction [Cadmium Chloride results in increased phosphorylation of JUN protein]PMID:25374377
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