Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731071
Species: Homo sapiens
RGD Object: Gene
Symbol: AHR
Name: aryl hydrocarbon receptor
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AHRaffects activityEXP 6480464CTDCadmium Chloride affects the activity of AHR proteinPMID:23135549 PMID:25596134
AHRmultiple interactionsEXP 6480464CTD[Cadmium Chloride co-treated with Benzo(a)pyrene co-treated with lead acetate] results in increased activity of AHR protein; [Cadmium Chloride co-treated with Benzo(a)pyrene] results in increased activity of AHR protein; [sodium arsenite co-treated with Benzo(a)pyrene co-treated with Cadmium Chloride] results in increased activity of AHR proteinPMID:29502740
AHRaffects activityISOAhr (Rattus norvegicus)6480464CTDCadmium Chloride affects the activity of AHR proteinPMID:23135549
AHRaffects expressionISOAhr (Rattus norvegicus)6480464CTDCadmium Chloride affects the expression of AHR mRNAPMID:22127542
AHRdecreases expressionISOAhr (Mus musculus)6480464CTDCadmium Chloride results in decreased expression of AHR proteinPMID:35983679
AHRdecreases expressionISOAhr (Rattus norvegicus)6480464CTDCadmium Chloride results in decreased expression of AHR mRNAPMID:23135549
AHRincreases expressionISOAhr (Rattus norvegicus)6480464CTDCadmium Chloride results in increased expression of AHR proteinPMID:22127542
AHRmultiple interactionsISOAhr (Mus musculus)6480464CTDfargesin inhibits the reaction [Cadmium Chloride results in decreased expression of AHR protein]PMID:35983679
AHRmultiple interactionsISOAhr (Rattus norvegicus)6480464CTD11-fluoro-7-(14,14,15,15-pentafluoro-6-methyl-10-thia-6-azapentadecyl)estra-1,3-5(10)-triene-3,17-diol affects the reaction [Cadmium Chloride affects the expression of AHR mRNA]; Estradiol affects the reaction [Cadmium Chloride affects the expression of AHR mRNA]; Estradiol inhibits the reaction [Cadmium Chloride results in increased expression of AHR protein]PMID:22127542
Go Back to source page   Continue to Ontology report