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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70501
Species: Mus musculus
RGD Object: Gene
Symbol: Cdk2
Name: cyclin dependent kinase 2
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdk2decreases methylationISOCdk2 (Rattus norvegicus)6480464CTDCadmium Chloride results in decreased methylation of CDK2 promoterPMID:22457795
Cdk2increases expressionISOCDK2 (Homo sapiens)6480464CTDCadmium Chloride results in increased expression of CDK2 mRNA; Cadmium Chloride results in increased expression of CDK2 proteinPMID:20219890 PMID:26385184
Cdk2multiple interactionsISOCDK2 (Homo sapiens)6480464CTD[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with Wortmannin] inhibits the reaction [Cadmium Chloride results in increased expression of CDK2 protein]; RTKI cpd inhibits the reaction [Cadmium Chloride results in increased expression of CDK2 protein]PMID:26385184
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