GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | EGFR | increases expression | EXP | | 6480464 | CTD | Cadmium Chloride results in increased expression of EGFR; Cadmium Chloride results in increased expression of EGFR mRNA | PMID:18560533 PMID:21605009 PMID:26472689 PMID:26525392 | EGFR | increases phosphorylation | EXP | | 6480464 | CTD | Cadmium Chloride results in increased phosphorylation of EGFR protein | PMID:25118938 PMID:26385184 | EGFR | multiple interactions | EXP | | 6480464 | CTD | 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of EGFR protein]; [Cadmium Chloride results in increased abundance of Cadmium] promotes the reaction [SRC protein modified form binds to EGFR protein modified form]; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of EGFR protein; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of FOXO3 protein]; EGFR mutant form inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK1 protein]; EGFR mutant form inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; EGFR protein promotes the reaction [Cadmium Chloride results in increased phosphorylation of EGFR protein]; EGFR protein promotes the reaction [Cadmium Chloride results in increased phosphorylation of MAPK1 protein]; EGFR protein promotes the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; GPER1 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of EGFR protein]; NOTCH1 mutant form inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EGFR protein]; RTKI cpd inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EGFR protein] | PMID:23673518 PMID:25118938 PMID:25744307 PMID:26385184 PMID:31468104 | EGFR | increases expression | ISO | Egfr (Mus musculus) | 6480464 | CTD | Cadmium Chloride results in increased expression of EGFR mRNA | PMID:23948867 | EGFR | increases phosphorylation | ISO | Egfr (Mus musculus) | 6480464 | CTD | Cadmium Chloride results in increased phosphorylation of EGFR protein | PMID:23948867 PMID:27279585 | EGFR | increases phosphorylation | ISO | Egfr (Rattus norvegicus) | 6480464 | CTD | Cadmium Chloride results in increased phosphorylation of EGFR protein | PMID:19233221 | EGFR | multiple interactions | ISO | Egfr (Mus musculus) | 6480464 | CTD | 4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of EGFR protein]; [[[[Cadmium Chloride results in increased abundance of Reactive Oxygen Species] which results in increased activity of SRC protein] which results in increased activity of EGFR protein] which results in increased activity of STAT3 protein] promotes the reaction [STAT3 protein binds to STAT3 protein]; [[[Cadmium Chloride results in increased abundance of Reactive Oxygen Species] which results in increased activity of SRC protein] which results in increased activity of EGFR protein] which results in increased activity of STAT3 protein; [[Cadmium Chloride results in increased abundance of Reactive Oxygen Species] which results in increased activity of SRC protein] which results in increased activity of EGFR protein; [[RTKI cpd results in decreased activity of EGFR protein] co-treated with [SU 6656 results in decreased activity of SRC protein]] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of STAT3 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Cadmium Chloride results in increased expression of MT2 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [SU 6656 results in decreased activity of SRC protein] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of EGFR protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of EGFR mRNA]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EGFR protein]; Cadmium Chloride promotes the reaction [EGFR protein binds to SRC protein]; Cadmium Chloride promotes the reaction [EGFR protein binds to STAT3 protein]; Cadmium Chloride results in increased phosphorylation of and results in increased activity of EGFR protein; Gefitinib inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EGFR protein]; Resveratrol inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EGFR protein] | PMID:23376140 PMID:23948867 PMID:27279585 | EGFR | multiple interactions | ISO | Egfr (Rattus norvegicus) | 6480464 | CTD | KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EGFR protein]; RTKI cpd inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EGFR protein] | PMID:19233221 | | ||||||||||||||||||||||
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