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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69062
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdkn1b
Name: cyclin-dependent kinase inhibitor 1B
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1bdecreases expressionEXP 6480464CTDCadmium Chloride results in decreased expression of CDKN1B mRNAPMID:18636176
Cdkn1bincreases expressionEXP 6480464CTDCadmium Chloride results in increased expression of CDKN1B proteinPMID:16730872
Cdkn1bdecreases expressionISOCDKN1B (Homo sapiens)6480464CTDCadmium Chloride results in decreased expression of CDKN1B proteinPMID:27510461
Cdkn1bincreases expressionISOCDKN1B (Homo sapiens)6480464CTDCadmium Chloride results in increased expression of CDKN1B mRNAPMID:32512071 PMID:33129824
Cdkn1bmultiple interactionsISOCDKN1B (Homo sapiens)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CDKN1B protein; GJA1 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CDKN1B protein]PMID:28176351
Cdkn1bmultiple interactionsISOCdkn1b (Mus musculus)6480464CTDCadmium Chloride inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CDKN1B protein]; Cadmium Chloride promotes the reaction [Methylnitronitrosoguanidine results in decreased expression of CDKN1B mRNA]PMID:11516527 PMID:12135628
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