GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Htt | increases response to substance | EXP | | 6480464 | CTD | HTT gene mutant form results in increased susceptibility to Cadmium Chloride | PMID:30399392 | Htt | multiple interactions | EXP | | 6480464 | CTD | [HTT gene mutant form results in increased susceptibility to Cadmium Chloride] which results in increased activity of CASP3 protein; [HTT gene mutant form results in increased susceptibility to Cadmium Chloride] which results in increased activity of CASP9 protein; [HTT gene mutant form results in increased susceptibility to Cadmium Chloride] which results in increased expression of HMOX1 protein; [HTT gene mutant form results in increased susceptibility to Cadmium Chloride] which results in increased expression of NFE2L2 protein; [HTT gene mutant form results in increased susceptibility to Cadmium Chloride] which results in increased phosphorylation of PRKCD protein; HTT gene mutant form promotes the reaction [Cadmium Chloride results in decreased expression of SLC11A2 protein]; HTT gene mutant form promotes the reaction [Cadmium Chloride results in increased phosphorylation of MAPK1 protein]; HTT gene mutant form promotes the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein] | PMID:30399392 | | ||||||||||||||||||||||
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