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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 67402
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox2
Name: heme oxygenase 2
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox2affects expressionEXP 6480464CTDCadmium Chloride affects the expression of HMOX2 mRNAPMID:21442002
Hmox2decreases methylationEXP 6480464CTDCadmium Chloride results in decreased methylation of HMOX2 promoterPMID:22457795
Hmox2increases expressionEXP 6480464CTDCadmium Chloride results in increased expression of HMOX2 mRNAPMID:20107868
Hmox2multiple interactionsEXP 6480464CTD[Cadmium Chloride co-treated with Melatonin] results in decreased expression of HMOX2 mRNAPMID:21442002
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